23498

Role of globus pallidus GABA and opiate receptors in apomorphine circling in nigro-striatal lesioned rats.

Article date: 1982/4/1

PubMed ID: 23498

Journal name: Naunyn-Schmiedeberg's archives of pharmacology (ISSN: 0028-1298)

ABSTRACT

The effect of lesioning the ipsilateral globus pallidus (GP) on apomorphine-induced circling in nigro-striatal lesioned rats was investigated. A GP electrolesion almost abolished circling whereas a kainic acid lesion partly antagonized circling. Drugs that affect GABA and opiate receptors were injected in GP through a cannula. Circling was antagonized by the GABA antagonists picrotoxin and bicuculline, the GABA agonist muscimol and by baclofen. Opiate receptor agonists including morphine, levorphanol, [D-Ala2, D-Leu5]-enkephalin and beta-endorphin had no effect on circling in GP. Ethylketazocine caused a pronounced, naloxone-reversible slowing of apomorphine circling. Apomorphine-induced circling behaviour may be modulated by GP GABA receptors and kappa-type opiate receptors.

Author List: Slater P

Publication Types: Journal Article

Substances mentioned in the article: Receptors, Cell Surface; Receptors, GABA-A; Receptors, Opioid; Apomorphine; Dopamine;

Mesh terms: Animals; Apomorphine/pharmacology; Corpus Striatum/physiology; Dopamine/physiology; Electric Stimulation; Female; Globus Pallidus/drug effects; Humans; Rats; Rats, Inbred Strains; Receptors, Cell Surface/drug effects; Receptors, GABA-A; Receptors, Opioid/drug effects; Stereotaxic Techniques; Stereotyped Behavior/drug effects; Substantia Nigra/physiology;

Citations: - 4959016

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