23498

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23498 [2018/11/20 14:26] (current)
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 +====== Role of globus pallidus GABA and opiate receptors in apomorphine circling in nigro-striatal lesioned rats.======
 +
 +** Article date:** 1982/4/1
 +~~META:date created = 1982-04-01~~
 +
 +** PubMed ID: 23498 **
 +
 +** Journal name: Naunyn-Schmiedeberg'​s archives of pharmacology (ISSN: 0028-1298) **
 +
 +** ABSTRACT **
 +
 +The effect of lesioning the ipsilateral globus pallidus (GP) on apomorphine-induced circling in nigro-striatal lesioned rats was investigated. A GP electrolesion almost abolished circling whereas a kainic acid lesion partly antagonized circling. Drugs that affect GABA and opiate receptors were injected in GP through a cannula. Circling was antagonized by the GABA antagonists picrotoxin and bicuculline,​ the GABA agonist muscimol and by baclofen. Opiate receptor agonists including morphine, levorphanol,​ [D-Ala2, D-Leu5]-enkephalin and beta-endorphin had no effect on circling in GP. Ethylketazocine caused a pronounced, naloxone-reversible slowing of apomorphine circling. Apomorphine-induced circling behaviour may be modulated by GP GABA receptors and kappa-type opiate receptors.
 +
 +===== ===== 
 +
 +Author List: Slater P
 +
 +Publication Types: Journal Article
 +
 +Substances mentioned in the article: Receptors, Cell Surface; Receptors, GABA-A; Receptors, Opioid; Apomorphine;​ Dopamine; ​
 +
 +Mesh terms: Animals; Apomorphine/​pharmacology;​ Corpus Striatum/​physiology;​ Dopamine/​physiology;​ Electric Stimulation;​ Female; Globus Pallidus/​drug effects; Humans; Rats; Rats, Inbred Strains; Receptors, Cell Surface/​drug effects; Receptors, GABA-A; Receptors, Opioid/drug effects; Stereotaxic Techniques; Stereotyped Behavior/​drug effects; Substantia Nigra/​physiology; ​
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 +Citations: ​  - //​[[4959016]]//​
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 +{{tag> Receptors,​_Cell_Surface Receptors,​_GABA-A Receptors,​_Opioid Dopamine Apomorphine }}
 +
 +{{keywords>​ Receptors, Cell Surface, Receptors, GABA-A, Receptors, Opioid, Dopamine, Apomorphine}}
 +
  
23498.txt · Last modified: 2018/11/20 14:26 (external edit)