Article date: 1990/6/1
PubMed ID: 2356203
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
Eight days of treatment with two low doses of tetrahydroaminoacridine (THA), given once daily, substantially improved radial maze performance in two groups of rats which showed persistent deficits either after ibotenic acid lesions at the source of forebrain cholinergic projections, or after 28 weeks treatment with alcohol (20% v/v) in drinking water. However, in immature, aged or aged and alcohol-treated rats, acetylcholine content was not significantly affected in any of the brain areas measured, even though the treatment regime had proved behaviourally effective. Inhibition of brain acetylcholinesterase activity was only marginally increased by this treatment regime. Thus, if THA influences behaviour by enhancing cholinergic transmission, its effects do not appear to be related to its activity as a cholinesterase inhibitor, and alternative mechanisms of action should be investigated.
Author List: Hodges H, Ribeiro A M, Gray J A, Marchbanks R M
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Aminoacridines; Ibotenic Acid; Ethanol; Tacrine; Acetylcholinesterase; Acetylcholine;
Mesh terms: Acetylcholine/metabolism; Acetylcholinesterase/metabolism; Aging/metabolism; Aminoacridines/pharmacology; Animals; Brain/drug effects; Cognition/drug effects; Ethanol/toxicity; Female; Ibotenic Acid/toxicity; Male; Memory/drug effects; Rats; Rats, Inbred Strains; Tacrine/pharmacology;