Article date: 1990/6/1
PubMed ID: 2356216
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
In the present study we evaluated the effect of intracerebroventricular (ICV) administration of naloxone on feeding induced by food deprivation, norepinephrine (NE), muscimol and neuropeptide Y (NPY). Naloxone (200, 100 and 50 micrograms ICV) decreased deprivation-induced feeding. In contrast, only the 200 micrograms dose of naloxone decreased NE-induced feeding and the 200 and 100 micrograms doses decreased muscimol-induced feeding. Eating stimulated by central administration of NPY was potently decreased by doses of naloxone ranging from 10-200 micrograms.
Author List: Levine A S, Grace M, Billington C J
Publication Types: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Neuropeptide Y; Muscimol; Naloxone; Norepinephrine;
Mesh terms: Animals; Drug Interactions; Eating/drug effects; Food Deprivation; Injections, Intraventricular; Male; Muscimol/pharmacology; Naloxone/pharmacology; Neuropeptide Y/pharmacology; Norepinephrine/pharmacology; Rats; Rats, Inbred Strains;