Article date: 1990/5/31
PubMed ID: 2377321
Journal name: Neuroscience letters (ISSN: 0304-3940)
The present study was designed to determine the effects of partial cholinergic denervation on parietal cortical corticotropin-releasing hormone-like immunoreactivity (CRH-LI) in the rat at different ages. Young adult rats received either unilateral or bilateral ibotenic acid infusions into their nucleus basalis, destroying most of the acetylcholinesterase-positive neurons in that region. Parietal cortical levels of CRH-LI were assayed 2.5, 10, 14 and 19 months after placement of nucleus basalis lesions. Parietal CRH-LI was elevated at 10, 14 and 19 months in bilaterally lesioned animals, while unilateral lesions had no effect on CRH-LI.
Author List: Millard W J, Arendash G W, Dunn A J, Meyer E M
Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Ibotenic Acid; Corticotropin-Releasing Hormone;
Mesh terms: Aging/metabolism; Animals; Basal Ganglia/growth & development; Cerebral Cortex/growth & development; Corticotropin-Releasing Hormone/metabolism; Ibotenic Acid; Male; Radioimmunoassay; Rats; Rats, Inbred Strains;