Effects of nucleus basalis lesions on cerebral cortical concentrations of corticotropin-releasing hormone (CRH)-like immunoreactivity in the rat.

Article date: 1990/5/31

PubMed ID: 2377321

Journal name: Neuroscience letters (ISSN: 0304-3940)


The present study was designed to determine the effects of partial cholinergic denervation on parietal cortical corticotropin-releasing hormone-like immunoreactivity (CRH-LI) in the rat at different ages. Young adult rats received either unilateral or bilateral ibotenic acid infusions into their nucleus basalis, destroying most of the acetylcholinesterase-positive neurons in that region. Parietal cortical levels of CRH-LI were assayed 2.5, 10, 14 and 19 months after placement of nucleus basalis lesions. Parietal CRH-LI was elevated at 10, 14 and 19 months in bilaterally lesioned animals, while unilateral lesions had no effect on CRH-LI.

Author List: Millard W J, Arendash G W, Dunn A J, Meyer E M

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Ibotenic Acid; Corticotropin-Releasing Hormone;

Mesh terms: Aging/metabolism; Animals; Basal Ganglia/growth & development; Cerebral Cortex/growth & development; Corticotropin-Releasing Hormone/metabolism; Ibotenic Acid; Male; Radioimmunoassay; Rats; Rats, Inbred Strains;

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