Ibotenic acid lesions of the medial prefrontal cortex potentiate FG-7142-induced attenuation of exploratory activity in the rat.

Article date: 1990/7/1

PubMed ID: 2377670

Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)


Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic beta-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enhanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.

This document is available from: http://directlinks.cc/files/muscimol/2377670.pdf

Author List: Jaskiw G E, Weinberger D R

Publication Types: Journal Article

Substances mentioned in the article: Carbolines; Oxazoles; Ibotenic Acid; FG 7142;

Mesh terms: Animals; Anxiety/chemically induced; Carbolines/pharmacology; Cerebral Cortex/drug effects; Exploratory Behavior/drug effects; Ibotenic Acid/toxicity; Male; Motor Activity/drug effects; Oxazoles/toxicity; Rats; Rats, Inbred Strains; Stress, Physiological/physiopathology;

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