Article date: 1990/7/1
PubMed ID: 2377670
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
Six weeks after induction of bilateral sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC), groups of rats were injected with the anxiogenic beta-carboline FG-7142 (15 mg/kg IP) or vehicle (VEH) before exposure to a novel open field. The attenuation of exploratory activity by FG-7142 was markedly enhanced in the MPFC-lesioned rats. The results suggest that the behavioral effects of MPFC lesions may be amplified under stressful conditions. Secondly, the inhibition of exploratory activity by FG-7142 does not depend on its action within the MPFC.
Author List: Jaskiw G E, Weinberger D R
Publication Types: Journal Article
Substances mentioned in the article: Carbolines; Oxazoles; Ibotenic Acid; FG 7142;
Mesh terms: Animals; Anxiety/chemically induced; Carbolines/pharmacology; Cerebral Cortex/drug effects; Exploratory Behavior/drug effects; Ibotenic Acid/toxicity; Male; Motor Activity/drug effects; Oxazoles/toxicity; Rats; Rats, Inbred Strains; Stress, Physiological/physiopathology;