2424017

Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors.

Article date: 1990/12/1

PubMed ID: 2424017

Journal name: British journal of pharmacology (ISSN: 0007-1188)

ABSTRACT

Ethanol administered i.v. or into the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane inhibits baroreflex bradycardia elicited by phenylephrine. This effect is prevented or reduced by pretreatment of rats with 3-mercaptopropionic acid, bicuculline, or RO 15-4513. Intra-NTS injection of muscimol also inhibits baroreflex bradycardia and causes a pressor response which is potentiated by intra-NTS ethanol. It is proposed that ethanol inhibits baroreflex bradycardia, at least in part, by potentiating the action of endogenous gamma-aminobutyric acid (GABA) at GABAA receptors in the NTS or its vicinity.

This document is available from: http://directlinks.cc/files/muscimol/2424017.pdf

Author List: Varga K, Kunos G

Publication Types: Journal Article

Substances mentioned in the article: Azides; Receptors, GABA-A; Benzodiazepines; Muscimol; Ethanol; Ro 15-4513; 3-Mercaptopropionic Acid; Bicuculline;

Mesh terms: 3-Mercaptopropionic Acid/pharmacology; Anesthesia; Animals; Azides/pharmacology; Benzodiazepines/pharmacology; Bicuculline/pharmacology; Blood Pressure/drug effects; Brain Stem/physiology; Ethanol/pharmacology; Heart Rate/drug effects; Male; Microinjections; Muscimol/administration & dosage; Pressoreceptors/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/physiology; Reflex/drug effects;

Citations: - 692829

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