2424059

Possible involvement of low and high affinity GABA receptors in the chloride influx into synaptosomes.

Article date: 1986/3/1

PubMed ID: 2424059

Journal name: Revista espanola de fisiologia (ISSN: 0034-9402)

ABSTRACT

Experiments carried out in the absence or presence of GABA using a synaptosomal fraction from which endogenous GABA was as far as possibly eliminated, seem to indicate that both GABA receptors are involved in the chloride channel opening. This hypothesis is supported by results obtained in the presence of GABA agonist (muscimol) or drugs which are related to the complex GABA receptor-ionophore (diazepam and phenobarbital).

Author List: Sánchez C, Giménez A, Cañadas S, González M P

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Chlorides; Ion Channels; Receptors, GABA-A; gabase; Muscimol; gamma-Aminobutyric Acid; Aldehyde Oxidoreductases; 4-Aminobutyrate Transaminase; Diazepam; Phenobarbital;

Mesh terms: 4-Aminobutyrate Transaminase/metabolism; Aldehyde Oxidoreductases/metabolism; Animals; Chlorides/metabolism; Diazepam/pharmacology; Ion Channels/metabolism; Muscimol/pharmacology; Phenobarbital/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/classification; Synaptosomes/metabolism; gamma-Aminobutyric Acid/metabolism;

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