Article date: 1986/5/15
PubMed ID: 2425286
Journal name: Neuroscience letters (ISSN: 0304-3940)
In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.
Author List: Struble R G, Lehmann J, Mitchell S J, McKinney M, Price D L, Coyle J T, DeLong M R
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Ibotenic Acid; Choline O-Acetyltransferase;
Mesh terms: Animals; Cerebral Cortex/enzymology; Choline O-Acetyltransferase/metabolism; Diencephalon/cytology; Ibotenic Acid; Macaca fascicularis; Macaca mulatta; Neurons/physiology; Parasympathetic Nervous System/physiology; Staining and Labeling; Telencephalon/cytology;