Maintenance of cortical somatostatin and monoamine levels in the rat does not require intact cholinergic innervation.

Article date: 1987/3/17

PubMed ID: 2436718

Journal name: Brain research (ISSN: 0006-8993)


Levels of somatostatin, noradrenaline, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were unchanged in rat neocortex 3 or 6 months after ibotenic acid lesion of the ipsilateral nucleus basalis that reduced cortical choline acetyltransferase levels by over 60%. These results render unlikely the possibility that non-cholinergic neurotransmitter deficits in Alzheimer's disease cortex are the consequence of cholinergic degeneration.

Author List: Fine A, Pittaway K, de Quidt M, Czudek C, Reynolds G P

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Biogenic Amines; Serotonin; Somatostatin; Hydroxyindoleacetic Acid; Dopamine; Norepinephrine;

Mesh terms: Animals; Basal Ganglia/physiology; Biogenic Amines/analysis; Cerebral Cortex/analysis; Cholinergic Fibers/physiology; Dopamine/analysis; Hydroxyindoleacetic Acid/analysis; Male; Norepinephrine/analysis; Rats; Rats, Inbred Strains; Serotonin/analysis; Somatostatin/analysis; Substantia Innominata/physiology;

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