Article date: 1987/3/17
PubMed ID: 2436718
Journal name: Brain research (ISSN: 0006-8993)
Levels of somatostatin, noradrenaline, dopamine, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were unchanged in rat neocortex 3 or 6 months after ibotenic acid lesion of the ipsilateral nucleus basalis that reduced cortical choline acetyltransferase levels by over 60%. These results render unlikely the possibility that non-cholinergic neurotransmitter deficits in Alzheimer's disease cortex are the consequence of cholinergic degeneration.
Author List: Fine A, Pittaway K, de Quidt M, Czudek C, Reynolds G P
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Biogenic Amines; Serotonin; Somatostatin; Hydroxyindoleacetic Acid; Dopamine; Norepinephrine;
Mesh terms: Animals; Basal Ganglia/physiology; Biogenic Amines/analysis; Cerebral Cortex/analysis; Cholinergic Fibers/physiology; Dopamine/analysis; Hydroxyindoleacetic Acid/analysis; Male; Norepinephrine/analysis; Rats; Rats, Inbred Strains; Serotonin/analysis; Somatostatin/analysis; Substantia Innominata/physiology;