Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain.

Article date: 1987/5/12

PubMed ID: 2440512

Journal name: Brain research (ISSN: 0006-8993)


The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.

This document is available from: http://directlinks.cc/files/muscimol/2440512.pdf

Author List: Schwartz R D, Wess M J, Labarca R, Skolnick P, Paul S M

Publication Types: Journal Article

Substances mentioned in the article: Chlorides; Ion Channels; Receptors, GABA-A; Muscimol;

Mesh terms: Adrenalectomy; Animals; Brain/drug effects; Chlorides/metabolism; In Vitro Techniques; Ion Channels/drug effects; Male; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Stress, Physiological/metabolism; Swimming; Synaptosomes/drug effects;

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