Article date: 1987/5/12
PubMed ID: 2440512
Journal name: Brain research (ISSN: 0006-8993)
The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.
Author List: Schwartz R D, Wess M J, Labarca R, Skolnick P, Paul S M
Publication Types: Journal Article
Substances mentioned in the article: Chlorides; Ion Channels; Receptors, GABA-A; Muscimol;
Mesh terms: Adrenalectomy; Animals; Brain/drug effects; Chlorides/metabolism; In Vitro Techniques; Ion Channels/drug effects; Male; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Stress, Physiological/metabolism; Swimming; Synaptosomes/drug effects;