Depletion in substance P- and neurokinin A-like immunoreactivity in substantia nigra after ibotenate-induced lesions of striatum.

Article date: 1987/12/1

PubMed ID: 2448711

Journal name: Neuroscience research (ISSN: 0168-0102)


Changes in substance P (SP)- and neurokinin A (NKA)-like immunoreactivity (LI) in the rat substantia nigra (SN) after striatal lesion produced by ibotenate were studied using immunohistochemical methods. Compared to the SN on the control side, both SP- and NKA-LI were dramatically depleted in the SN on the lesion side. These findings are consistent with the existence of SP- and/or NKA-containing neurons in the striatum projecting to the SN.

Author List: Arai H, Sirinathsinghji D J, Emson P C

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Neuropeptides; Ibotenic Acid; Substance P; Neurokinin A;

Mesh terms: Animals; Corpus Striatum/physiology; Ibotenic Acid; Immunohistochemistry; Male; Neurokinin A; Neuropeptides/immunology; Rats; Rats, Inbred Strains; Substance P/immunology; Substantia Nigra/immunology;

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