Article date: 1987/12/1
PubMed ID: 2448711
Journal name: Neuroscience research (ISSN: 0168-0102)
Changes in substance P (SP)- and neurokinin A (NKA)-like immunoreactivity (LI) in the rat substantia nigra (SN) after striatal lesion produced by ibotenate were studied using immunohistochemical methods. Compared to the SN on the control side, both SP- and NKA-LI were dramatically depleted in the SN on the lesion side. These findings are consistent with the existence of SP- and/or NKA-containing neurons in the striatum projecting to the SN.
Author List: Arai H, Sirinathsinghji D J, Emson P C
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Neuropeptides; Ibotenic Acid; Substance P; Neurokinin A;
Mesh terms: Animals; Corpus Striatum/physiology; Ibotenic Acid; Immunohistochemistry; Male; Neurokinin A; Neuropeptides/immunology; Rats; Rats, Inbred Strains; Substance P/immunology; Substantia Nigra/immunology;