Decreased sensitivity to benzodiazepine receptor agonists and increased sensitivity to inverse agonists following chronic treatments: evidence for separate mechanisms.

Article date: 1988/1/1

PubMed ID: 2459923

Journal name: Advances in biochemical psychopharmacology (ISSN: 0065-2229)


Author List: Stephens D N, Schneider H H, Weidmann R, Zimmermann L

Publication Types: Comparative Study; Journal Article

Substances mentioned in the article: Anti-Anxiety Agents; Appetite Depressants; Carbolines; Chlorides; Ion Channels; Receptors, GABA-A; Benzodiazepines; Muscimol; FG 7142; lormetazepam; Lorazepam; Diazepam; Pentylenetetrazole;

Mesh terms: Animals; Anti-Anxiety Agents/pharmacology; Appetite Depressants/pharmacology; Benzodiazepines; Carbolines/pharmacology; Chlorides/metabolism; Diazepam/pharmacology; Drug Interactions; Drug Tolerance; Exploratory Behavior/drug effects; Ion Channels/metabolism; Kindling, Neurologic/drug effects; Locomotion/drug effects; Lorazepam/analogs & derivatives; Mice; Muscimol/metabolism; Pentylenetetrazole/pharmacology; Rats; Receptors, GABA-A/drug effects;

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