Estrogen modulation of the gamma-aminobutyric acid receptor complex in the central nervous system of rat.

Article date: 1988/3/1

PubMed ID: 2472478

Journal name: The Journal of pharmacology and experimental therapeutics (ISSN: 0022-3565)


Administration of estradiol benzoate to ovariectomized rats results in an increased binding of [3H]muscimol, [3H]diazepam and 35S-t-butylbicyclophosphorothionate in various areas of the central nervous system of rats. The effect is dose-dependent and its onset can be observed as early as 12 hr after s.c. administration of the hormone. The various binding activities are differentially affected by the hormonal treatment: the maximal effect observed for [3H]diazepam binding is in the cerebellum (+42%), for [3H]muscimol binding in the frontal cortex (+84%) and for 35S-t-butylbicyclophosphorothionate binding in the striatum (+46%) indicating that the activities of the sites are not under the same cellular regulatory control. The estrogen-induced increase in [3H]diazepam binding sites does not result in an increased protection against chemoconvulsants such as pentylenetetrazole.

Author List: Perez J, Zucchi I, Maggi A

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Estrogens; Receptors, GABA-A; Muscimol; RNA; tert-butylbicyclophosphorothionate; Diazepam;

Mesh terms: Animals; Brain/drug effects; Bridged Bicyclo Compounds/metabolism; Bridged Bicyclo Compounds, Heterocyclic; Diazepam/metabolism; Dose-Response Relationship, Drug; Estrogens/pharmacology; Female; Muscimol/pharmacology; RNA/metabolism; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Seizures/chemically induced;

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