Article date: 1989/1/1
PubMed ID: 2505893
Journal name: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie (ISSN: 0764-4469)
Ibotenic acid microinjections have been realized at the level of the mesencephalic reticular formation and the posterior hypothalamus in 7 cats. This technique has led to a quasi-total destruction of cell bodies in the two areas (including the histaminergic neurons). 2 to 3 days after such lesions, there were no major effects on behavioral waking. These results do not favor the hypothesis of the existence of a waking system at the level of the mesencephalic reticular formation and/or posterior hypothalamus.
Author List: Denoyer M, Buda C, Jouvet M
Publication Types: English Abstract; Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Ibotenic Acid;
Mesh terms: Animals; Cats; Female; Hypothalamus/physiology; Hypothalamus, Posterior/drug effects; Ibotenic Acid/pharmacology; Male; Mesencephalon/drug effects; Sleep Stages/drug effects; Wakefulness;