2509219

Suppression of GABA-induced chloride current by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2).

Article date: 1989/8/3

PubMed ID: 2509219

Journal name: European journal of pharmacology (ISSN: 0014-2999)

ABSTRACT

The effect of a convulsive agent, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), on the GABA-induced chloride current (ICl) in dissociated mouse sensory neurons was investigated using the whole cell clamp method. Trp-P-2 reversibly suppressed the GABA-induced ICl in a dose-dependent manner. The IC50 for Trp-P-2 on the ICl evoked by 3 microM GABA was 11.1 microM. Ro15-1788 had no effect on the suppressive action of Trp-P-2. These results suggest that the observed effect of Trp-P-2 is mediated by its action as an antagonist at GABAA receptors.

This document is available from: http://directlinks.cc/files/muscimol/2509219.pdf

Author List: Kanai Y, Aosaki T, Wada O, Manabe S

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Carbolines; Chlorides; GABA Antagonists; Taurine; Muscimol; Flumazenil; 3-amino-1-methyl-5H-pyrido(4,3-b)indole; Alanine;

Mesh terms: Alanine/pharmacology; Animals; Carbolines/pharmacology; Chlorides/metabolism; Flumazenil/pharmacology; GABA Antagonists; Ganglia, Spinal/cytology; Male; Membrane Potentials/drug effects; Mice; Mice, Inbred Strains; Muscimol/pharmacology; Neurons, Afferent/drug effects; Taurine/pharmacology;

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