Pregnancy-induced alterations of GABAA receptor sensitivity in maternal brain: an antecedent of post-partum 'blues'?

Article date: 1989/3/20

PubMed ID: 2539888

Journal name: Brain research (ISSN: 0006-8993)


Pregnancy increases affinity of [3H]muscimol binding to GABAA receptors in the rat forebrain. Post-partum, the receptor affinity is further increased concomitantly with a reduction of the receptor density. These changes may result from an action of endogenous placental and adrenal steroids, tetrahydroprogesterone and tetrahydrodeoxycorticosterone, which in vitro behave as allosteric agonists of GABAA receptors. The alterations may contribute to the psychological phenomena associated with pregnancy and the puerperium.

This document is available from: http://directlinks.cc/files/muscimol/2539888.pdf

Author List: Majewska M D, Ford-Rice F, Falkay G

Publication Types: Journal Article

Substances mentioned in the article: Receptors, GABA-A; Muscimol; Pregnanolone;

Mesh terms: Animals; Female; Frontal Lobe/drug effects; Gestational Age; Muscimol/metabolism; Postpartum Period/metabolism; Pregnancy; Pregnancy, Animal/metabolism; Pregnanolone/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects;

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