Article date: 1989/2/20
PubMed ID: 2540881
Journal name: Brain research (ISSN: 0006-8993)
Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are preferentially involved in this GABAergic seizure suppression mechanism. Adult rats were intranigrally infused with muscimol (GABAA receptor agonist), bicuculline (GABAA receptor antagonist) or baclofen (GABAB receptor agonist) and were exposed to flurothyl seizures. Results indicated that while infusions of muscimol had an anticonvulsant effect, infusions of bicuculline had a proconvulsant effect. Baclofen infusions were found to have no effect on seizures. These findings suggest an involvement of the nigral GABAA receptors in the mediation of seizures in adult rats.
Author List: Sperber E F, Wurpel J N, Zhao D Y, Moshé S L
Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Receptors, GABA-A; Muscimol; Baclofen; Bicuculline;
Mesh terms: Animals; Baclofen/pharmacology; Bicuculline/pharmacology; Dose-Response Relationship, Drug; Male; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Seizures/metabolism; Substantia Nigra/metabolism;