Ibotenic acid stimulates D-[3H]aspartate release from cultured cerebellar granule cells.

Article date: 1989/1/30

PubMed ID: 2541382

Journal name: Neuroscience letters (ISSN: 0304-3940)


The release of D-[3H]aspartate from cultured cerebellar granule cells can be evoked by potassium depolarization or by superfusion with the excitatory amino acids glutamic and aspartic acids. The latter phenomenon is not mediated by N-methyl-D-aspartate (NMDA)-, kainate- or quisqualate-preferring receptors, but is stimulated by ibotenic acid. Excitatory amino acid-stimulated D-[3H]aspartate release is antagonised by L-serine-O-phosphate and riluzole. These compounds did not block potassium-stimulated D-[3H]aspartate release. This pharmacology resembles an excitatory amino acid receptor coupled to inositol phosphate (PI) turnover.

Author List: Hubert J P, Doble A

Publication Types: Journal Article

Substances mentioned in the article: Amino Acids; Oxazoles; Receptors, Amino Acid; Receptors, Cell Surface; Thiazoles; Phosphoserine; Ibotenic Acid; Aspartic Acid; Riluzole;

Mesh terms: Amino Acids/pharmacology; Animals; Aspartic Acid/pharmacokinetics; Cells, Cultured; Cerebellum/cytology; Ibotenic Acid/pharmacology; Oxazoles/pharmacology; Phosphoserine/pharmacology; Rats; Receptors, Amino Acid; Receptors, Cell Surface/drug effects; Riluzole; Thiazoles/pharmacology;

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