Article date: 1989/5/22
PubMed ID: 2543483
Journal name: Brain research (ISSN: 0006-8993)
Injections of muscimol (12.5 or 25 ng bilaterally), a GABAA agonist, into the posterior nuclei of the thalamus suppressed generalized convulsive seizures in the spontaneously epileptic Mongolian gerbil. This anticonvulsant effect was dose-dependent and was reversed by picrotoxin (10 ng bilaterally), a GABAA antagonist. Bilateral intrathalamic injections of 1-baclofen (50 ng), an agonist of the GABAB receptor, were ineffective in suppressing seizures in this model. These results suggest that GABAergic transmission within the thalamus is involved in the control or the genesis of some generalized convulsive seizures.
Author List: Lee R J, Depaulis A, Lomax P, Olsen R W
Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Anticonvulsants; Receptors, GABA-A; Picrotoxin; Muscimol; Baclofen;
Mesh terms: Animals; Anticonvulsants/pharmacology; Baclofen/pharmacology; Dose-Response Relationship, Drug; Epilepsy/metabolism; Female; Gerbillinae; Male; Muscimol/pharmacology; Picrotoxin/pharmacology; Receptors, GABA-A/drug effects; Thalamic Nuclei/drug effects;