2545458

Antagonist profile of 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylate at excitatory amino acid receptors in the neonatal rat spinal cord.

Article date: 1989/4/12

PubMed ID: 2545458

Journal name: European journal of pharmacology (ISSN: 0014-2999)

ABSTRACT

In the neonatal rat spinal cord, 6,7-dichloro-3-hydroxy-2- quinoxalinecarboxylate antagonised responses mediated at both N-methyl-D-aspartate (NMDA) and non-NMDA receptors. The antagonism of responses to NMDA was unsurmountable and mediated via an antagonist action at the allosterically-linked strychnine-insensitive glycine site. At non-NMDA receptors, 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylate appeared to act as a competitive antagonist at low concentrations and a non-competitive antagonist at higher concentrations. In contrast to published data, this antagonist did not distinguish between the responses mediated by DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) and kainate.

Author List: Birch P J, Grossman C J, Hayes A G

Publication Types: Journal Article

Substances mentioned in the article: Quinoxalines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylic acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Kainic Acid;

Mesh terms: Animals; Animals, Newborn/metabolism; Ibotenic Acid/analogs & derivatives; Kainic Acid/pharmacology; Quinoxalines/pharmacology; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface/drug effects; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter/drug effects; Spinal Cord/drug effects; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid;

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