Induction of protooncogene fos by extracellular signals in primary glial cell cultures.

Article date: 1989/6/1

PubMed ID: 2547086

Journal name: Journal of neuroscience research (ISSN: 0360-4012)


In the present study various extracellular factors, acting through different second messenger systems, were examined for their capacity to increase the level of c-fos mRNA in primary glial cell cultures. In particular EGF, 12-O-tetradecanoylphorbol 13-acetate, the beta-adrenergic agonist isoproterenol, and the glutamate agonists, ibotenic and quisqualic acid, were studied. All the extracellular stimuli tested induced a rapid and transient increase in c-fos mRNA level in glial cell cultures regardless of the signal transduction pathway and the final effect on cell proliferation.

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Author List: Condorelli D F, Kaczmarek L, Nicoletti F, Arcidiacono A, Dell'Albani P, Ingrao F, Magrì G, Malaguarnera L, Avola R, Messina A

Publication Types: Journal Article

Substances mentioned in the article: DNA-Binding Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; RNA, Messenger; Ibotenic Acid; Epidermal Growth Factor; Cyclic AMP; Tetradecanoylphorbol Acetate;

Mesh terms: Animals; Astrocytes/cytology; Brain/cytology; Cell Division/drug effects; Cells, Cultured; Cyclic AMP/metabolism; DNA-Binding Proteins/metabolism; Epidermal Growth Factor/pharmacology; Ibotenic Acid/pharmacology; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-fos; RNA, Messenger/metabolism; Rats; Second Messenger Systems/drug effects; Tetradecanoylphorbol Acetate/pharmacology;

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