[The characteristics of [3H]muscimol binding to the synaptic membranes of the cerebral cortex in the progeny of rats subjected to deprivation of the paradoxical sleep phase during pregnancy].

Article date: 1989/1/1

PubMed ID: 2553136

Journal name: Nauchnye doklady vysshei shkoly. Biologicheskie nauki (ISSN: 0470-4606)


White rats were subjected to REM-sleep deprivation during 14-20 days of pregnancy. [3H]muscimol binding level of neocortex synaptosomal membranes was significantly higher in their offsprings as compared with the control ones. Possible ways of GABA-ergic system malformations are discussed.

Author List: Zhulin V V, Zabludovskiń≠ A L

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: Receptors, GABA-A; Tritium; Muscimol;

Mesh terms: Animals; Cerebral Cortex/analysis; Female; Muscimol/analysis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A/analysis; Sleep Deprivation/physiology; Sleep, REM/physiology; Synaptic Membranes/analysis; Tritium;

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