[The role of GABA-A and GABA-B receptors in the development of amnesia].

Article date: 1989/7/1

PubMed ID: 2554616

Journal name: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (ISSN: 0044-4677)


The paper deals with analysis of the influence of blockade of separate components of benzodiazepine-GABA-ionophore complex on the recovery of memory trace amnesia under GABA-A and GABA-B receptors activation in the experiments with conditioned reaction of passive avoidance of mice. Activation of GABA-A receptors did not change the behavioural amnesia manifestation at all terms of testing. Activation of GABA-B receptors before learning and amnestic influence caused spontaneous recovery of avoidance reaction. Blockade of chloride channel by picrotoxin and of benzodiazepine receptor by flumazepil restored the reproduction of the memory trace disturbed against the background of GABA-B receptors activation. Systemic flumazepil administration contributed to the memory trace reproduction against the background of GABA-A receptors activation by muscimol in the dose of 0.5 mg/kg. In conditions of amnesia development against the background of muscimol in the dose of 1 mg/kg the blockade of any component of benzodiazepine-GABA-ionophore complex was not effective. The obtained data testify that activation of GABA-A and GABA-B receptors changes the amnesia development and correction of amnesia memory trace by the blockade of separate components of benzodiazepine-GABA-ionophore complex.

This document is available from: http://directlinks.cc/files/muscimol/2554616.pdf

Author List: Parkhomenko R I, Dubrovina N I, Il'iuchenok R Iu

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: Receptors, GABA-A; Picrotoxin; Muscimol; Flumazenil; Baclofen; Bicuculline;

Mesh terms: Amnesia/etiology; Amnesia, Retrograde/etiology; Animals; Avoidance Learning/drug effects; Baclofen/pharmacology; Bicuculline/pharmacology; Conditioning, Classical/drug effects; Dose-Response Relationship, Drug; Flumazenil/pharmacology; Male; Memory/drug effects; Mice; Mice, Inbred BALB C; Muscimol/pharmacology; Picrotoxin/pharmacology; Receptors, GABA-A/drug effects;

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