Article date: 1989/3/1
PubMed ID: 2554670
Journal name: Zhongguo yao li xue bao = Acta pharmacologica Sinica (ISSN: 0253-9756)
The GABA receptor agonists GABA (400 micrograms icv) and muscimol (1 microgram icv) induced hypotension in urethane-anesthetized rats, while the GABA receptor antagonist bicuculline (2 micrograms icv) elicited hypertension. An endogenous GABA receptor binding inhibitor (1 mg), prepared from bovine cerebellum, showed bicuculline-like hypertensive action in a dose-dependent manner. It was antagonized by icv muscimol, but not by the alpha 2-adrenoceptor agonist clonidine. These in vivo results agree quite well with our previous in vitro receptor binding assay experiments.
Author List: Cai N S, Xiao W B, Zhou T C
Publication Types: English Abstract; Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Receptors, GABA-A; Muscimol; Clonidine; Bicuculline;
Mesh terms: Animals; Bicuculline/pharmacology; Blood Pressure/drug effects; Clonidine/pharmacology; Female; Injections, Intraventricular; Male; Muscimol/pharmacology; Rats; Receptors, GABA-A/drug effects;