2558901

Modulation of uterine GABAA receptors during gestation and by tetrahydroprogesterone.

Article date: 1989/12/12

PubMed ID: 2558901

Journal name: European journal of pharmacology (ISSN: 0014-2999)

ABSTRACT

Binding of a GABAA receptor agonist, [3H]muscimol, was studied in rat uterine membranes of non-pregnant rats and those at days 15 and 19 of pregnancy. Also, an interaction of the uterine GABAA receptors with tetrahydroprogesterone was examined. At day 15 of gestation [3H]muscimol binding was twice as high as in non-pregnant rats, but at day 19 it was reduced. These changes resulted from an increase of the receptor affinity and decrease of the receptor density, at days 15 and 19, respectively. Since tetrahydroprogesterone, in vitro, also increased [3H]muscimol binding, we propose that this steroid may participate in regulation of uterine function during pregnancy.

This document is available from: http://directlinks.cc/files/muscimol/2558901.pdf

Author List: Majewska M D, Falkay G, Baulieu E E

Publication Types: Journal Article

Substances mentioned in the article: Pregnanes; Receptors, GABA-A; Muscimol; Pregnanolone;

Mesh terms: Animals; Female; Kinetics; Muscimol/metabolism; Pregnancy; Pregnancy, Animal/metabolism; Pregnanes/pharmacology; Pregnanolone/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism; Uterus/metabolism;

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