Article date: 1989/7/1
PubMed ID: 2559758
Journal name: Neuron (ISSN: 0896-6273)
Three major subtypes of glutamate receptors that are coupled to cation channels are known. Recently an additional subtype that is coupled to G proteins and stimulates inositol phospholipid metabolism (the metabotropic glutamate receptor) has been proposed. The pharmacological characteristics of this receptor have now been examined. Although it shares some agonists with N-methyl-D-aspartate- and quisqualate-subtype receptors, it shares virtually no antagonists with any of the three cation channel-coupled receptor subtypes. Thus the metabotropic glutamate receptor belongs to a receptor category that is completely different from that of the other three receptor subtypes, not only functionally, but also pharmacologically.
Author List: Sugiyama H, Ito I, Watanabe M
Publication Types: Journal Article
Substances mentioned in the article: Glutamates; Neuromuscular Depolarizing Agents; Oxadiazoles; RNA, Messenger; Receptors, Glutamate; Receptors, Neurotransmitter; Homocysteine; Ibotenic Acid; Aspartic Acid; homocysteinesulfinic acid; N-Methylaspartate; Quisqualic Acid; Kainic Acid;
Mesh terms: Animals; Aspartic Acid/analogs & derivatives; Brain Chemistry; Electrophysiology; Glutamates/metabolism; Homocysteine/analogs & derivatives; Ibotenic Acid/pharmacology; Kainic Acid/pharmacology; Microinjections; N-Methylaspartate; Neuromuscular Depolarizing Agents/pharmacology; Oocytes/metabolism; Oxadiazoles/pharmacology; Quisqualic Acid; RNA, Messenger/genetics; Rats; Receptors, Glutamate; Receptors, Neurotransmitter/classification; Xenopus;