[The electrical activity of the hippocampus in rats centrally administered GABA agonists and antagonists].

Article date: 1989/12/1

PubMed ID: 2560722

Journal name: Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova (ISSN: 0015-329X)


In unrestrained rats, frequency ranges of dorsal hippocampus electrograms were studied after intraventricular injections of the GABA, muscimol, baclofen, bicuculline and picrotoxin. The data obtained corroborates the idea of an interrelationship between the agonists and antagonists of the GABA receptors. A possibility of participation of these receptors in the formation and/or modulation of total electrical hippocampal activity, is discussed.

Author List: Iarkov A V, Vorob'ev V V, Gal'chenko A A, Kovalev G I

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: GABA Antagonists; Receptors, GABA-A; Picrotoxin; Muscimol; gamma-Aminobutyric Acid; Baclofen; Bicuculline;

Mesh terms: Animals; Baclofen/pharmacology; Bicuculline/pharmacology; Drug Interactions; Electrodes, Implanted; Electroencephalography/drug effects; GABA Antagonists; Hippocampus/drug effects; Injections, Intraventricular; Male; Muscimol/pharmacology; Picrotoxin/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; gamma-Aminobutyric Acid/pharmacology;

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