Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytes.

Article date: 1989/1/1

PubMed ID: 2565288

Journal name: Glia (ISSN: 0894-1491)


Addition of quisqualate (a heterocyclic analogue of glutamate) reduced [methyl-3H]thymidine incorporation and cell proliferation in primary cultures of rat cortical astrocytes. The inhibitory action of quisqualate was mimicked by glutamate and ibotenate, whereas kainate, N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) were inactive. These results suggest that activation of a specific class of excitatory amino acid receptors contributes to the regulation of growth and proliferation of glial cells in primary culture.

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Author List: Condorelli D F, Ingrao F, Magri G, Bruno V, Nicoletti F, Avola R

Publication Types: Journal Article

Substances mentioned in the article: Glutamates; Oxadiazoles; Receptors, Amino Acid; Receptors, Cell Surface; Ibotenic Acid; Glutamic Acid; Quisqualic Acid; Thymidine;

Mesh terms: Animals; Astrocytes/cytology; Brain/cytology; Cell Division; Cells, Cultured; Glutamates/pharmacology; Glutamic Acid; Ibotenic Acid/pharmacology; Oxadiazoles/pharmacology; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface/drug effects; Thymidine;

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