2569917

Complex responses activated by ibotenate in postnatal rat hippocampal neurons.

Article date: 1989/8/7

PubMed ID: 2569917

Journal name: Brain research (ISSN: 0006-8993)

ABSTRACT

The actions of the excitatory amino acid ibotenate were investigated in postnatal rat hippocampal neurons. In neurons voltage clamped at negative membrane potentials using low-chloride internal solutions, ibotenate responses consist of an inward cationic current and two outward currents. The inward current is inhibited by 2-amino-5-phosphonovalerate (APV), a selective N-methyl-D-aspartate (NMDA) antagonist. The two outward currents consist of a picrotoxin and bicuculline-sensitive chloride current and a slowly developing calcium activated potassium current. The bicuculline sensitive current appears to be the product of contamination of ibotenate samples with the gamma-aminobutyric acid (GABA) agonist muscimol and not the result of a direct action of ibotenate.

This document is available from: http://directlinks.cc/files/muscimol/2569917.pdf

Author List: Zorumski C F, Todd R D, Clifford D B

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Oxazoles; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Ibotenic Acid; 2-Amino-5-phosphonovalerate; Valine;

Mesh terms: 2-Amino-5-phosphonovalerate; Action Potentials/drug effects; Animals; Cells, Cultured; Hippocampus/drug effects; Ibotenic Acid/pharmacology; Oxazoles/pharmacology; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter/drug effects; Valine/analogs & derivatives;

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