A biochemical correlate of the critical period for synaptic modification in the visual cortex.

Article date: 1989/11/3

PubMed ID: 2573152

Journal name: Science (New York, N.Y.) (ISSN: 0036-8075)


Stimulation of phosphoinositide hydrolysis by excitatory amino acids was studied in synaptoneurosomes of kitten striate cortex at several postnatal ages. Ibotenate and glutamate stimulated phosphoinositide turnover during the second and third postnatal months; N-methyl-D-aspartate and DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) were without effect. The developmental profile of ibotenate-stimulated phosphoinositide turnover parallels the postnatal changes in cortical susceptibility to visual deprivation. The transient increase in ibotenate-stimulated phosphoinositide turnover does not occur in visual cortex of kittens reared in complete darkness.

This document is available from: http://directlinks.cc/files/muscimol/2573152.pdf

Author List: Dudek S M, Bear M F

Publication Types: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Glutamates; Phosphatidylinositols; Ibotenic Acid; Aspartic Acid; Glutamic Acid; N-Methylaspartate; Carbachol;

Mesh terms: Aging; Animals; Aspartic Acid/pharmacology; Carbachol/pharmacology; Cattle; Glutamates/pharmacology; Glutamic Acid; Ibotenic Acid/pharmacology; N-Methylaspartate; Ocular Physiological Phenomena; Phosphatidylinositols/metabolism; Synapses/drug effects; Vision, Ocular; Visual Cortex/growth & development;

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