Article date: 1989/12/1
PubMed ID: 2584272
Journal name: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (ISSN: 0271-678X)
Local cerebral blood flow was measured in five regions of rat cortex immediately following intravenous administration of the gamma-aminobutyric acid (GABA) agonist muscimol. In contrast to recent observations, no increases in blood flow were found at either of the two time points analysed, and the data revealed that decreases in blood flow previously reported 30 min after muscimol treatment were in evidence as early as 30 s. These results are totally consistent with the conclusion that the overall effects of GABA agonists in the intact animal are to reduce blood flow in line with reduced metabolic demand in the neuropil. However, the heterogeneity of the reductions in cortical blood flow found here possibly suggests a biological role for vascular GABA systems in providing a mitigating influence on fluctuating tissue perfusion.
Author List: Kelly P A, Faulkner A J, Burrow A P
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Muscimol;
Mesh terms: Animals; Blood Pressure/drug effects; Cerebral Cortex/blood supply; Cerebrovascular Circulation/drug effects; Male; Muscimol/pharmacology; Organ Specificity; Rats; Rats, Inbred Strains; Regional Blood Flow/drug effects;