Effect of GABA, muscimol and picrotoxin given in third ventricle on serum cholinesterases and monoamine oxidase and on plasma succinic dehydrogenase in rats.

Article date: 1989/10/1

PubMed ID: 2620959

Journal name: Indian journal of physiology and pharmacology (ISSN: 0019-5499)


Effect of injection in third ventricle of GABA, the GABA agonist muscimol, and the GABA antagonist picrotoxin on the activities of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO) in serum and succinic dehydrogenase (SDH) in plasma has been studied. Surprisingly, the AChE, BuChE, MAO and SDH enzymes activity were inhibited by GABA and muscimol, while they were enhanced by picrotoxin.

Author List: Rattan A K, Mangat H K

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Picrotoxin; Muscimol; gamma-Aminobutyric Acid; Succinate Dehydrogenase; Monoamine Oxidase; Acetylcholinesterase; Butyrylcholinesterase; Cholinesterases;

Mesh terms: Acetylcholinesterase/blood; Animals; Butyrylcholinesterase/blood; Cholinesterases/blood; Injections, Intraventricular; Male; Monoamine Oxidase/blood; Muscimol/administration & dosage; Picrotoxin/administration & dosage; Rats; Succinate Dehydrogenase/blood; gamma-Aminobutyric Acid/administration & dosage;

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