2703874

GABA(A) receptors in the pars compacta and GABA(B) receptors in the pars reticulata of rat substantia nigra modulate the striatal dopamine release.

Article date: 2002/6/18

PubMed ID: 2703874

Journal name: Neurochemical research (ISSN: 0364-3190)

ABSTRACT

The nigral GABAergic regulation of striatal dopamine release was investigated using voltammetry in freely moving rats. The local administration of muscimol (1 nM) in the substantia nigra pars compacta, but not in the substantia nigra pars reticulata, increased the striatal dopamine release. In contrast, the administration of baclofen (10 nM) in the substantia nigra pars reticulata, but not in the substantia nigra pars compacta, produced a decrease of the striatal dopamine release. Opposite effects were respectively observed after administration of GABA(A) and GABA(B) antagonists. These data lead us to suggest a differential presynaptic GABAergic control of the dopaminergic neurotransmission through GABA(A) receptors in the substantia nigra pars compacta, and GABA(B) receptors in the substantia nigra pars reticulata.

Author List: Balon Norbert, Kriem Badreddine, Weiss Michel, Rostain Jean-Claude

Publication Types: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Receptors, GABA-B; Muscimol; Baclofen; Dopamine; Bicuculline;

Mesh terms: Animals; Baclofen/pharmacology; Bicuculline/pharmacology; Corpus Striatum/metabolism; Dopamine/metabolism; Electrochemistry; Male; Muscimol/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, GABA-A/physiology; Receptors, GABA-B/physiology; Substantia Nigra/drug effects;

Citations: - 4145914

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