[Effect of gamma-aminobutyric acid on the development of catatonia-like states in mice].

Article date: 1989/1/1

PubMed ID: 2707411

Journal name: Farmakologiia i toksikologiia (ISSN: 0014-8318)


Catatony-like states including periods of tonic immobility and locomotor paroxysms were induced in mice by a single pinch at the scruff of the neck. GABA-positive drugs (aminooxyacetic acid 20 mg/kg, muscimol 0.5 mg/kg) increased the duration of periods of immobility as compared with control. GABA-negative drugs (thiosemicarbazide 5 mg/kg, bicuculline 3 mg/kg in combination with aminooxyacetic acid) increased only the number and duration of locomotor paroxysms.

Author List: Kudriavtseva N N, Bakshtanovskaia I V

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: Semicarbazides; Aminooxyacetic Acid; Muscimol; gamma-Aminobutyric Acid; thiosemicarbazide; Bicuculline;

Mesh terms: Aminooxyacetic Acid/pharmacology; Animals; Bicuculline/pharmacology; Brain Chemistry/drug effects; Catatonia/etiology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Muscimol/pharmacology; Semicarbazides/pharmacology; gamma-Aminobutyric Acid/analysis;

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