Article date: 1989/3/1
PubMed ID: 2740418
Journal name: Pharmacology, biochemistry, and behavior (ISSN: 0091-3057)
Microinjections of various doses of muscimol into the median raphe nucleus, the dorsal raphe nucleus or the caudal portion of the ventral tegmental area elicited dose-dependent increases in locomotor activity. In contrast, injections into the rostral portion of the ventral tegmental area or the midline pontine tegmentum caudal to the median raphe were ineffective. Lower doses of muscimol were required to produce hyperactivity after injections into the median raphe than after injections into any of the other sites. These findings suggest that the median raphe nucleus is the most sensitive site in the paramedian tegmentum for the elicitation of hyperactivity by muscimol.
Author List: Wirtshafter D, Klitenick M A
Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.
Substances mentioned in the article: Muscimol;
Mesh terms: Animals; Dose-Response Relationship, Drug; Male; Microinjections; Motor Activity/drug effects; Muscimol/pharmacology; Rats; Rats, Inbred Strains; Tegmentum Mesencephali/drug effects;