Qualitative and quantitative changes in monoamine oxidase activity after acute third ventricle treatment of GABA, muscimol, and picrotoxin in rat.

Article date: 1989/1/1

PubMed ID: 2759416

Journal name: Gegenbaurs morphologisches Jahrbuch (ISSN: 0016-5840)


The effect of acute IIIrd ventricle injection of GABA, muscimol, and picrotoxin on the activity of monoamine oxidase (MAO) has been investigated in serum and a few hypothalamic nuclei of the rat brain using biochemical, histochemical, and cytophotometric techniques. Biochemical estimation demonstrated a significant reduction in MAO enzyme activity after GABA and muscimol injection, whereas picrotoxin produced pronounced increase in the enzyme activity. Histochemical and cytophotometric studies confirmed the biochemical findings. Even in brain, GABA and muscimol inhibited and picrotoxin stimulated the MAO activity. From the above findings, it may be concluded that GABA, muscimol, and picrotoxin regulate the MAO activity, possible mechanisms for which are being discussed.

Author List: Rattan A K, Dhatt R K, Mangat H K

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Picrotoxin; Muscimol; gamma-Aminobutyric Acid; Monoamine Oxidase;

Mesh terms: Animals; Brain/drug effects; Cytophotometry; Histocytochemistry; Injections, Intraventricular; Male; Monoamine Oxidase/analysis; Muscimol/administration & dosage; Picrotoxin/administration & dosage; Rats; Rats, Inbred Strains; gamma-Aminobutyric Acid/administration & dosage;

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