Caudato-nigral transmission in the substantia nigra pars reticulata neurons changes with recovery from circling movements induced by microinfusion of ibotenic acid. II. Electrophysiological study on synaptic transmission.

Article date: 1989/6/1

PubMed ID: 2771206

Journal name: Neuroscience research (ISSN: 0168-0102)


Caudato-nigral synaptic transmission was examined by stimulation of the caudate nucleus while recording from nigral neurons in cats recovering from circling movements induced by a unilateral circumscribed lesion in the substantia nigra pars reticulata after microinfusion of ibotenic acid. Extra- and intracellular recording from neurons in lesion-spared areas of the substantia nigra pars reticulata indicated that the caudato-nigral synaptic action on the side ipsilateral to the lesion exhibited a shorter duration of inhibition and a larger amplitude of excitation as a means of compensating for the circling movements.

Author List: Udo M, Shimada T, Hirose S, Kitamura T, Yamamoto H

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Neurotoxins; Oxazoles; Picrotoxin; Ibotenic Acid;

Mesh terms: Action Potentials/drug effects; Animals; Cats; Caudate Nucleus/drug effects; Functional Laterality/physiology; Ibotenic Acid/toxicity; Neurotoxins/pharmacology; Oxazoles/toxicity; Picrotoxin/pharmacology; Stereotyped Behavior/drug effects; Substantia Nigra/drug effects;

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