[3H]-dopamine release from the rabbit retina.

Article date: 1980/1/1

PubMed ID: 27790

Journal name: Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology (ISSN: 0065-6100)


[3H]-Dopamine was found to be released from the rabbit retina in vitro by light stimulation, by 40 mM K+, and by alpha-MSH (alpha-Melanocyte-Stimulating Hormone) down to about 10(-7) M. The effect of alpha-MSH was dose-dependent. A number of known and putative retinal neurotransmitters and agonists (GABA, muscimol, glutamic acid, kainic acid, glycine, and carbachol, all 10(-4) M) were without significant effect. The results show that it is unlikely that there are excitatory receptors on the retinal dopaminergic neurons to any of the conventional transmitters. Further, alpha-MSH seems of interest as a possible neuroactive retinal substance, which was previously not been suspected.

Author List: Bauer B, Ehinger B, Aberg L

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Neurotransmitter Agents; Tritium; Melanocyte-Stimulating Hormones; Potassium; Dopamine;

Mesh terms: Animals; Dopamine/metabolism; Dose-Response Relationship, Drug; Melanocyte-Stimulating Hormones/pharmacology; Neurotransmitter Agents/antagonists & inhibitors; Photic Stimulation; Potassium/pharmacology; Rabbits; Retina/metabolism; Tritium;

Citations: - 436145

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