Ibotenic acid-induced nigral lesion and limbic seizure in cats.

Article date: 1989/10/2

PubMed ID: 2790479

Journal name: Brain research (ISSN: 0006-8993)


The degenerative lesions of bilateral substantia nigra (SN) were made by means of microinjections of ibotenic acid (IBO) solutions and influences upon kainic acid (KA)-induced seizures were studied. IBO solutions were injected bilaterally into SN and circumscribed degenerative lesions were made within the bilateral SN. In a control group, phosphate buffer solutions were injected in the bilateral SN. More than one week after the procedures, 1 microgram KA was injected into unilateral amygdala via implanted cannula and limbic seizures were induced. The destruction of SN accelerated the secondary generalization of the limbic seizure within 3 days after the KA injection while no secondary generalization was observed within 3 days in the control group. The fact suggests that GABAergic systems of the substantia nigra and/or ascending norepinephrine pathway have a strong inhibitory influence on the secondary generalization of limbic seizures. The hypothesis of nigral mechanisms as a control system for secondary generalization is discussed.

Author List: Tanaka T, Tanaka S, Kaijima M, Yonemasu Y

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Oxazoles; Ibotenic Acid; Kainic Acid;

Mesh terms: Animals; Brain Diseases/chemically induced; Cats; Electroencephalography; Female; Ibotenic Acid; Kainic Acid; Limbic System/physiopathology; Male; Oxazoles; Seizures/chemically induced; Substantia Nigra/physiology;

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