Evidence for a chronic loss of inhibition in the hippocampus after kindling: electrophysiological studies.

Article date: 1989/9/1

PubMed ID: 2792071

Journal name: Epilepsy research (ISSN: 0920-1211)


Rats were kindled with either of 2 protocols: (1) a rapidly recurring hippocampal seizure (RRHS) paradigm in which 10 sec stimulus trains were delivered every 5 min through hippocampal electrodes; and (2) a traditional approach in which 1 sec stimulus trains were given to the amygdala once daily. Three groups of kindled rats were prepared: (1) one of amygdala-kindled rats that had experienced 9-15 seizures; (2) one of RRHS-kindled rats that had experienced 96 seizures; and (3) one of RRHS-overkindled rats that had experienced 144-336 seizures. After a 1 month seizure-free period, the animals were anesthetized with urethane and measurements were made on the potency of paired pulse inhibition in the CA1 region of the hippocampus. All groups of kindled animals were found to have significantly less paired pulse inhibition than control rats. This decrement was confined to interpulse intervals less than or equal to 70 msec. The amount of inhibition lost correlated with the number of seizure that had occurred. The GABAergic agonist muscimol restored paired pulse inhibition in kindled animals for interpulse intervals less than or equal to 70 msec towards normal values. These results indicate that not only RRHS, but also other modes of kindling, reduced GABAergic inhibition in the CA1 region of the hippocampus and that this diminution was long-lasting, if not permanent.

This document is available from: http://directlinks.cc/files/muscimol/2792071.pdf

Author List: Kapur J, Michelson H B, Buterbaugh G G, Lothman E W

Publication Types: Journal Article; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Muscimol; gamma-Aminobutyric Acid;

Mesh terms: Animals; Hippocampus/metabolism; Kindling, Neurologic; Male; Muscimol/pharmacology; Neural Inhibition; Rats; gamma-Aminobutyric Acid/physiology;

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