Article date: 1989/1/1
PubMed ID: 2796603
Journal name: Life sciences (ISSN: 0024-3205)
The effects of GABAergic agents on non-convulsive epilepsy were studied by intracerebroventricular injections of muscimol and bicuculline in WAG/Rij rats. The WAG/Rij rat strain is recognized as an animal model for human absence epilepsy. EEG registrations and behavioural observations showed that muscimol dose-dependently increased the non-convulsive absence epilepsy. Besides this, it induced EEG spikes and body twitches. Bicuculline induced spikes and body twitches as well but decreased the non-convulsive epilepsy. All effects of muscimol can be blocked by bicuculline and vice versa, which suggests that the observed effects are genuine GABAA effects. These results implicate that non-convulsive epilepsy can be caused by a GABAergic hyperfunction.
Author List: Peeters B W, van Rijn C M, Vossen J M, Coenen A M
Publication Types: Journal Article
Substances mentioned in the article: Muscimol; gamma-Aminobutyric Acid; Bicuculline;
Mesh terms: Animals; Behavior, Animal/drug effects; Bicuculline/administration & dosage; Electroencephalography; Epilepsy/physiopathology; Female; Injections, Intraventricular; Male; Muscimol/administration & dosage; Rats; Rats, Inbred Strains; gamma-Aminobutyric Acid/physiology;