[Effect of activation and blocking of the GABA-ergic system during disorders of memory trace reproduction].

Article date: 1987/7/1

PubMed ID: 2823503

Journal name: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (ISSN: 0044-4677)


Analysis of the effects of activation and blocade of GABA-ergic system showed significant changes in the level of reproduction of conditioned reaction of passive avoidance in mice–lowering under administration of muscimol and baclopfen and increase under administration of picrotoxin and bicucullin in a dose of 1 mg/kg. Sharp lowering was observed of the efficiency of activating influence of drugs depressing the activity of GABA-ergic system at a long interval from the moment of administration of “psychogenic” amnestic agent. Dependence was established of the drugs influence on the type of memory disturbance: higher value of bicucullin and picrotoxin in retrieval of memory trace disturbed by cycloheximide in comparison to “psychogenic” amnesia. On the basis of the obtained results a suggestion is made on the significance of GABA-ergic mechanisms in regulation of reproduction processes.

Author List: Dubrovina N I, Il'iuchenok R Iu

Publication Types: English Abstract; Journal Article

Substances mentioned in the article: Receptors, GABA-A; Picrotoxin; Bicuculline;

Mesh terms: Amnesia/physiopathology; Animals; Avoidance Learning/drug effects; Bicuculline/pharmacology; Conditioning, Classical/drug effects; Male; Memory/drug effects; Mice; Mice, Inbred BALB C; Picrotoxin/pharmacology; Reaction Time/drug effects; Receptors, GABA-A/drug effects;

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