Potent inhibitory GABAB receptors in stimulated guinea-pig taenia coli.

Article date: 1987/11/1

PubMed ID: 2829050

Journal name: Neuropharmacology (ISSN: 0028-3908)


gamma-Aminobutyric acid (GABA, half-maximal inhibitory concentration, IC50 = 9.9 microM) and (-)-baclofen (IC50 = 4.5 microM) but not 10(-4) M muscimol, exerted a presynaptic inhibitory effect on cholinergic transmission in field-stimulated guinea-pig taenia coli preparations, in vitro. The antagonism by 10(-5) M (1S, 9R)-bicuculline methiodide was not specific for GABA agonists. The results suggest that the GABA receptors involved were of type B.

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Author List: Rónai A Z, Kardos J, Simonyi M

Publication Types: Journal Article

Substances mentioned in the article: Receptors, GABA-A; Muscimol; Atropine; Baclofen; Acetylcholine; Norepinephrine; Bicuculline;

Mesh terms: Acetylcholine/pharmacology; Animals; Atropine/pharmacology; Baclofen/pharmacology; Bicuculline/pharmacology; Colon/drug effects; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscimol/pharmacology; Muscle, Smooth/drug effects; Norepinephrine/pharmacology; Receptors, GABA-A/drug effects;

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