Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task.

Article date: 1992/4/15

PubMed ID: 2829245

Journal name: Proceedings of the National Academy of Sciences of the United States of America (ISSN: 0027-8424)


This experiment examined the effects of diazepam (DZP) on acquisition and retention of an inhibitory avoidance response by rats with excitotoxic-induced lesions of central (CE), lateral (LAT), or basolateral (BL) amygdala nuclei. Sham-operated and lesioned rats received i.p. injections of DZP (2.0 mg per kg of body weight) 30 min before training in a continuous multiple-trial inhibitory avoidance task. Retention was tested 48 h later. Acquisition was not impaired by the lesions or the DZP. Retention was impaired in animals with CE and LAT lesions in comparison with sham-operated controls. DZP impaired retention in the sham-operated controls as well as CE- and LAT-lesioned animals but did not affect retention in animals with BL lesions. These findings indicate that the DZP-induced anterograde amnesia for inhibitory avoidance training is mediated through influences involving the BL amygdala nucleus.

Author List: Tomaz C, Dickinson-Anson H, McGaugh J L

Publication Types: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

Substances mentioned in the article: Ibotenic Acid; Diazepam;

Mesh terms: Amnesia/physiopathology; Amygdala/drug effects; Animals; Avoidance Learning/drug effects; Diazepam/pharmacology; Ibotenic Acid/toxicity; Male; Organ Specificity; Rats; Rats, Inbred Strains; Reference Values;

Citations: - 2329367

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