Article date: 1988/4/1
PubMed ID: 2833276
Journal name: Biochemical pharmacology (ISSN: 0006-2952)
The pineal hormone, melatonin, enhanced the sodium-independent binding of [3H]-gamma-aminobutyric acid ([3H]GABA) and [3H]muscimol in the rat cerebral cortex in vitro. This effect was augmented by preincubation of synaptic membranes with melatonin but was abolished by preincubation with Triton X-100. Saturation binding studies using [3H]GABA (2.5 to 1000 nM) indicated that the melatonin-induced enhancement of binding is due to an increase in low-affinity GABAA binding sites. These findings suggest that the central effects of melatonin involve modulation of GABAergic function.
Author List: Coloma F M, Niles L P
Publication Types: Journal Article; Research Support, Non-U.S. Gov't
Substances mentioned in the article: Receptors, GABA-A; Tritium; Muscimol; Polyethylene Glycols; gamma-Aminobutyric Acid; Octoxynol; Melatonin; Diazepam;
Mesh terms: Animals; Brain/drug effects; Diazepam/pharmacology; Dose-Response Relationship, Drug; Freezing; In Vitro Techniques; Male; Melatonin/pharmacology; Muscimol/metabolism; Octoxynol; Polyethylene Glycols/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/drug effects; Tritium; gamma-Aminobutyric Acid/metabolism;