Article date: 1988/4/27
PubMed ID: 2840300
Journal name: European journal of pharmacology (ISSN: 0014-2999)
Racemic baclofen, (-)-baclofen and muscimol depressed all spontaneously firing locus coeruleus neurons tested in a slice preparation. Racemic phaclofen (100 microM; 1 mM) moderately antagonized the effects of racemic baclofen without antagonizing those of muscimol. Bicuculline (10, 30, 100 microM) potently antagonized the action of muscimol without affecting the inhibition of baclofen. Phaclofen and bicuculline had no pronounced effect on the spontaneous discharge rate of cells. The results suggests that there are GABAA and GABAB receptors in the locus coeruleus.
Author List: Olpe H R, Steinmann M W, Hall R G, Brugger F, Pozza M F
Publication Types: Journal Article
Substances mentioned in the article: Receptors, GABA-A; phaclofen; Muscimol; Baclofen;
Mesh terms: Animals; Baclofen/analogs & derivatives; In Vitro Techniques; Locus Coeruleus/drug effects; Male; Muscimol/pharmacology; Neurons/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism;