2840300

GABAA and GABAB receptors in locus coeruleus: effects of blockers.

Article date: 1988/4/27

PubMed ID: 2840300

Journal name: European journal of pharmacology (ISSN: 0014-2999)

ABSTRACT

Racemic baclofen, (-)-baclofen and muscimol depressed all spontaneously firing locus coeruleus neurons tested in a slice preparation. Racemic phaclofen (100 microM; 1 mM) moderately antagonized the effects of racemic baclofen without antagonizing those of muscimol. Bicuculline (10, 30, 100 microM) potently antagonized the action of muscimol without affecting the inhibition of baclofen. Phaclofen and bicuculline had no pronounced effect on the spontaneous discharge rate of cells. The results suggests that there are GABAA and GABAB receptors in the locus coeruleus.

This document is available from: http://directlinks.cc/files/muscimol/2840300.pdf

Author List: Olpe H R, Steinmann M W, Hall R G, Brugger F, Pozza M F

Publication Types: Journal Article

Substances mentioned in the article: Receptors, GABA-A; phaclofen; Muscimol; Baclofen;

Mesh terms: Animals; Baclofen/analogs & derivatives; In Vitro Techniques; Locus Coeruleus/drug effects; Male; Muscimol/pharmacology; Neurons/drug effects; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism;

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