[Immunomodulating effect of substances activating and blocking the GABA receptor-ionophore complex].

Article date: 1988/5/1

PubMed ID: 2842182

Journal name: Farmakologiia i toksikologiia (ISSN: 0014-8318)


A direct agonist of GABAA-receptor muscimol was shown to stimulate the immune response in CBA mice, whereas a competitive inhibitor of GABA-receptor bicuculline and a blocker of Cl-ionophores picrotoxin were found to inhibit the immune response. The immunomodulating effect of the GABAergic system was suggested.

Author List: Devoĭno L V, Beletskaia I O

Publication Types: Comparative Study; English Abstract; Journal Article

Substances mentioned in the article: Adjuvants, Immunologic; Ionophores; Receptors, GABA-A; Picrotoxin; Muscimol; Bicuculline;

Mesh terms: Adjuvants, Immunologic/pharmacology; Animals; Bicuculline/pharmacology; Dose-Response Relationship, Drug; Immunization; Ionophores/pharmacology; Mice; Mice, Inbred CBA; Muscimol/pharmacology; Picrotoxin/pharmacology; Receptors, GABA-A/drug effects; Rosette Formation; Spleen/drug effects;

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