2843383

Presynaptic modulation of the release of GABA by GABAA receptors in pars compacta and by GABAB receptors in pars reticulata of the rat substantia nigra.

Article date: 1988/6/10

PubMed ID: 2843383

Journal name: European journal of pharmacology (ISSN: 0014-2999)

ABSTRACT

The effect of GABA agonists and antagonists on K+-stimulated [3H]GABA release was studied to assess how presynaptic GABA receptors modulate GABA release. The release was affected in a quite different manner in the pars compacta and in the pars reticulata. Muscimol markedly inhibited the release from the pars compacta but had no effect on the release from the pars reticulata. Baclofen inhibited the release from the pars reticulata without affecting the release from the pars compacta. Bicuculline itself facilitated the release from the pars compacta but inhibited the release from the pars reticulata. Picrotoxin facilitated the release from the pars compacta and had no effect in the pars reticulata. The results suggest that the release of GABA from GABAergic terminals in the substantia nigra of the rat brain is modulated by GABAA autoreceptors in the pars compacta and by GABAB receptors in the pars reticulata.

This document is available from: http://directlinks.cc/files/muscimol/2843383.pdf

Author List: Floran B, Silva I, Nava C, Aceves J

Publication Types: Journal Article; Research Support, Non-U.S. Gov't

Substances mentioned in the article: Receptors, GABA-A; Muscimol; gamma-Aminobutyric Acid; Baclofen; Potassium; Bicuculline;

Mesh terms: Animals; Baclofen/pharmacology; Bicuculline/pharmacology; Brain/drug effects; In Vitro Techniques; Male; Muscimol/pharmacology; Potassium/pharmacology; Rats; Rats, Inbred Strains; Receptors, GABA-A/metabolism; Substantia Nigra/metabolism; gamma-Aminobutyric Acid/metabolism;

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