[Peculiarities of H3-muscimol binding to neocortex membranes of rats exposed to the effects of ethanol in the prenatal period].

Article date: 1988/10/1

PubMed ID: 2847833

Journal name: Biulleten' eksperimental'noi biologii i meditsiny (ISSN: 0365-9615)

ABSTRACT

White rats were subjected to ethanol exposure during 5-20 days of pregnancy. 3H-muscimol binding with synaptosomal neocortex membranes yielded from two month age offsprings was studied. 3H-muscimol binding level for experimental animals was 27% more than for control ones. Possible ways of GABAergic system malformation are discussed.

Author List: Zhulin V V, Zabludovskiĭ A L

Publication Types: English Abstract; Journal Article

Substances mentioned in the article: Receptors, GABA-A; Muscimol; Ethanol;

Mesh terms: Age Factors; Animals; Cerebral Cortex/metabolism; Ethanol/pharmacology; Female; Male; Muscimol/metabolism; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A/drug effects; Synaptosomes/metabolism;